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KMID : 1149220230310010021
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Korean Journal of Oriental Medical Prescription
2023 Volume.31 No. 1 p.21 ~ p.28
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Embryotoxic and Teratogenic Effects of Scolopendra Water Extract in Mice
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Lee Jeong-Min
Song Jun-Ho
Lee Soong-In
Ki Hyun-Jun
Shin In-Sik
Kim Sung-Ho
Moon Chang-Jong
Kim Joong-Sun
Lee Ji-Hye
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Abstract
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Objective : Scolopendra, a dried body of Scolopendra subspinipes mutilans, is one of Korean medicine. Several reports revealed that Scolopendra has therapeutic effects for arthritis, neuroinflammatory diseases and neuropathic pain. However, the fetal adaptive response or teratogenicity associated with administration of Scolopendra is unclear. Therefore, this study aimed to investigate the fetal toxicity effects that were induced following oral administration of Scolopendra water extract (SWE) in pregnant mice.
Methods : The pregnant mice were administrated SWE at dosed of 0, 100, 500 and 1000 mg/kg/day during gestation day 0-18. The mortality, body weight and clinical signs of pregnant mice were observed throughout experimental period. Also, the mortality and malformations in foetus were examined.
Results : No meaningful changes were observed in the mortality and clinical signs of pregnant mice between the normal control group and SWE administrated groups. Additionally, there are no significant changes in fetal mortalities, and malformations by SWE administration.
Conclusion : These results suggest that oral exposure to SWE during pregnancy at oral dosages up to 1000 mg/kg/day did not induce teratogenic toxicity in regard to fetal mortality and morphology.
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KEYWORD
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Scolopendra, Embryotoxicity, Teratogenic effect, pregnancy mice
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